•  
  •  
 

Abstract

MgO was synthesized using the hydrothermal technique. The autoclave containing material based on magnesium (NO3)2.6H2O was filled and heated to 100°C for three hours. Electrophoretic deposition technique was utilized to deposit MgO powder on a Ti plate. To examine its bioactivity (formation of hydroxyapatite (HAp), coated Ti with MgO was then submerged in concentrated SBF for a month. The formation of pure HAp without additional phases including calcium and phosphorus was confirmed by the XRD test. Scanning electron microscope (SEM) images refer to the formation of semispherical HAp nanoparticles with a diameter ≈ 20 nm. The inhibition zones of MgO were evaluated in order to assess their antibacterial effectiveness against S. aureus , S. epidermidis, Escherichia coli, Klebsiella pneumoniae and Candida albicans. MgO was not shown to have any antibacterial properties against the dangerous bacteria that were identified.

References

1] Guedes e Silvaa Cecilia Chaves, da Silva Rigob Eliana Cristina, Marchic Juliana, de Almeida Bressianic Ana Helena, Bressiani Jose Carlos. Hydroxyapatite coating on silicon nitride surfaces using the biomimetic method. Mater Res 2008;11(1):47e50.

[2] El Hadad AA, Peon Eduardo, Garc ía-Galvan Federico R, Barranco Violeta, Parra Juan, Jimenez-Morales Antonia, et al. Biocompatibility and corrosion protection behaviour of hydroxyapatite sol-gel-derived coatings on Ti6Al4V alloy. Materials 2017;10(2):94.

[3] Naser Dalal Mseer, Hashim Mustafa Shakir. The effects of targets' preparation conditions on the bioactivity and physical properties of abated hydroxyapatite by pulsed laser. Dig J Nanomater Biostruct 2019;14(2):447e61.

[4] Shin K, Acri Timothy, Geary Sean, Salem Aliasger K. Biomimetic mineralization of biomaterials using simulated body fluids for bone tissue engineering and regenerative medicine. Tissue Eng 2017;23(19e20):1169e80.

[5] Simkov a L, Nataliia Gorodylova, Zaneta Dohnalov a, Petra Sulcov a. In fluence of precipitation conditions on the synthesis of hydroxyapatite. Ceram Silik 2018;62(3):253e60.

[6] Stuart MAC, Huck Wilhelm TS, Genzer Jan, Müller Marcus, Ober Christopher, Stamm Manfred, et al. Emerging Fig. 6. Inhibition zones of MgO nanoparticles. AL-BAHIR (JOURNAL FOR ENGINEERING AND PURE SCIENCES) 2025;7:49e54 53 applications of stimuli-responsive polymer materials. Nat Mater 2010;9(2):101.

7] Zhang L, Chen Yupeng, Rodriguez Jose, Fenniri Hicham, Webster Thomas J. Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants. Int J Nanomed 2008;3(3):323.

[8] Hashim Mustafa Shakir, Khaleel Reem Saadi, Naser Dalal Mseer. Synthesis of oxides' nanoparticles to produce aqueous solutions for antimicrobial applications. Pak J Engg Appl Sci July, 2021;29:58e63.

[9] Toprak BÇ, Efkere HI, Aydõn SS, Tataroglu A, Oz çelik S. Structural morphological, optical and electrical characterization of MgO thin films grown by sputtering technique on different substrates. J Mater Sci Mater Electron 2024;35(20): 1389. https://doi.org/10.1007/s10854-024-13116-z.

[10] Mei S, Jiang F, Liu N, Feng Z, Zheng Y, Yang W, et al. Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. Nanomedicine 2024:1e12. https://doi.org/10.1080/ 17435889.2024.2382421.

[11] Hadia NMA, Mohamed HAH. Characteristics and optical properties of MgO nanowires synthesized by solvothermal method. Mater Sci Semicond Process 2015;29:238e44. https:// doi.org/10.1016/j.mssp.2014.03.049.

[12] Bian SW, Baltrusaitis J, Galhotra P, Grassian VH. A templatefree, thermal decomposition method to synthesize mesoporous MgO with a nanocrystalline framework and its application in carbon dioxide adsorption. J Mater Chem 2010;20(39):8705e10. https://doi.org/10.1039/C0JM01261K.

[13] Karimzadeh Zahra. Perovskite oxides as efficient bioactive inorganic materials in tissue engineering: a review. Mater Today Chem January 2024;35:101846.

[14] Naser Dalal Maseer, Lafta Sadeq H. Mustafa Shakir Hashim . Antioxidant activity and cytotoxicity of greigite nanoparticles synthesized by hydrothermal technique. Biotechnol Appl Biochem 2024:1e14. https://doi.org/10.1002/bab.2590.

[15] Wetteland Cheyann L, Sanchez Jorge de Jesus, Silken Christine A, Nguyen Nhu-Y Thi, Mahmood Omar, Liu Huinan. Dissociation of magnesium oxide and magnesium hydroxide nanoparticles in physiologically relevant fluids. J Nano Res 2018;20:215.

[16] Sahmania S, Samandorib SS, Khandanb A, Aghdamc MM. Influence of MgO nanoparticles on the mechanical properties of coated hydroxyapatite nanocomposite scaffolds produced via space holder technique: fabrication, characterization and simulation. J Mech Behav Biomed Mater 2019; 95:76e88.

[17] Sreekanth D, Rameshbabu N. Development and characterization of MgO/hydroxyapatite composite coating on AZ31 magnesium alloy by plasma electrolytic oxidation coupled with electrophoretic deposition. Mater Lett 2012;68:439e42.

[18] Slavica S, Sneha S, Francia, Jasmina V. Pure and multi metal oxide nanoparticles: synthesis, antibacterial and cytotoxic properties. J Nanobiotechnol 2016;14:73.

[19] Akindoyo JO, Beg MDH, Ghazali S, Islam MR, Jeyaratnama N, Yuvarajc AR. Polyurethane types, synthesis and applications. RSC Adv 2016;6:114453e82.

[20] Abbas Murtada Kutheir, Hashim Mustafa Shakir. Production of bioactive MgO nanoparticles via anodic technique. J Phys Conf 2022;2322:012082. https://doi.org/10.1088/1742-6596/ 2322/1/012082.

[21] Hashim Mustafa Shakir, Khaleel Reem Saadi. The bioactivities of prepared Ti, Zn, TiO 2 , ZnO and Al 2 O 3 nanoparticles by rapid breakdown anodization technique. Surf Interfaces 2020;20:100640.

[22] Hashim Mustafa Shakir, Abbas Murthada Kutheir. Investigation of biomimetic hydroxyapatite formation on titania nanoparticles and lobed nanotubes. Kuwait J Sci 2023;50:38.

[23] Mustafa SH, Mohammed F Al Marjani, Hussein TS, Reem S Kh, Zahraa A Kh, Aseel SJ. Investigation of the antibacterial activity of silver and Zinc containing solutions and Ag:ZnO films against some athogenic Bacteria. Jordan J Biol Sci 2019; 12(4).

[24] Vollath Dieter, Fischer Franz Dieter, Holec David. Surface energy of nanoparticles e influence of particle size and structure. Beilstein J Nanotechnol 2018 Aug 23;9:2265e76. https://doi.org/10.3762/bjnano.9.211.

[25] Kaygili O, Keser Serhat, Kom Mustafa, Bulut Niyazi, Dorozhkin Sergey V. The effect of simulating body fluid on the structural properties of hydroxyapatite synthesized in the presence of citric acid. Prog Biomater 2016;5(3e4):173e82.

[26] Sobczak-Kupiec A, Wzorek Zbigniew, Kijkowska Regina, Kowalski Zygmunt. Effect of calcination conditions of pork bone sludge on behaviour of hydroxyapatite in simulated body fluid. Bull Mater Sci 2013;36(4):755e64.

[27] Jiang J, Pi J, Cai J. The advancingof zinc oxide nanoparticles for biomedical applications. Bioinorgan Chem Appl 2018;18: 1062562.

Share

COinS